Chapter 1 Analysis of Gleevec (Please read the new book!)
Did you hear that our monitor is going to drop out of school?
In the dormitory of pharmacy majors at the Pharmaceutical University, someone suddenly spoke.
Faced with the sudden news, Lu Liang stopped what he was doing and looked at the roommate who spoke with some surprise.
A friend of mine just saw our monitor in the Academic Affairs Office. He is currently going through the withdrawal process. The roommate frowned and scrolled through his phone, as if even he couldn't believe it.
At this moment, the other two people in the dormitory also gathered around. They asked in confusion: What's going on? Why did the monitor suddenly drop out of school? You thought he was fine yesterday?
Yeah, I finally got into college, but if I drop out, won't the more than ten years of study be in vain?
The two were discussing, obviously unable to understand the monitor's behavior of dropping out of school.
I heard that his father had cancer, which was chronic myelogenous leukemia. The medicine to treat the disease was 40,000 bottles per bottle. The family could not afford it, so the monitor had no choice but to drop out of school.
When the roommate who was flipping through his cell phone said this, he shook his head with regret.
These words stunned the two roommates, and one of them opened his eyes in disbelief: What kind of medicine is it? It's so dark, 40,000 a bottle?
Looking at his two surprised roommates, Lu Liang seemed a little silent, and then he sighed.
Novartis' Gleevec, 40,000 bottles per bottle, is currently the only known specific drug on the market that can treat chronic myelogenous leukemia.
In this world, Gleevec's patent protection period has not yet expired, and second-generation therapeutic drugs have not yet appeared.
Novartis has absolute pricing power over Gleevec.
If he hadn't been a time traveler, Lu Liang might have been shocked by the price of the medicine just like his two roommates.
Isn't there any other medicine that can be substituted? a roommate asked with a frown.
The answer is, really not!
At least not yet in this world!
Lu Liang, who has also been a pharmacy student all his life, silently gave the answer in his heart.
Seeing that the dormitory was quiet, the roommate laughed dryly: That's not true. There are so many pharmaceutical companies in the country. After all, one of them must be able to develop drugs to treat chronic leukocytes, right?
Forget it, you count on them?
The roommate had just finished speaking when he was interrupted by the roommate holding the cell phone: If you don't believe it, you can check it online.
Then you will find that in the field of innovative drugs, domestic pharmaceutical companies have very few patents, almost none. Most of the patents are owned by Western pharmaceutical giants.
As he talked, the roommate seemed a little angry: It's too far!
Regarding the angry complaints from his angry young roommates, Lu Liang just listened silently and said nothing.
Because my roommate told the truth.
Lu Liang clearly knew that whether it was the world before traveling or the world he was in now.
In the field of innovative drug research, Western pharmaceutical giants have always occupied a near-monopoly position.
Someone sighed: There is no way. The research and development of an innovative drug often takes more than ten years, plus billions of funds are consumed. Among them, there is also the huge risk of losing all the money and time if it fails. .”
The most important thing is that by the time you develop innovative drugs, the patent protection period of other people's drugs may have expired. By then, there will be a lot of the same drugs, and your drugs will not be sold at all, and you will probably lose money. If there is no one left, who is willing to do it?”
These words immediately silenced the dormitory, and several people had frustrated looks on their faces.
In fact, this is just one of the more likely possibilities... Before your innovative drugs are developed, the patent protection period of those drugs will expire.
Or if R\u0026D fails and you go bankrupt, the latter is more likely.
Lu Liangliang silently added.
Then if you don't have money to buy medicine, wouldn't you just have to...wait to die?
I don't know who whispered something in a low voice, causing the entire dormitory to fall into that dead silence atmosphere again.
The answer is obvious.
A dull atmosphere enveloped the dormitory.
Before getting sick, everyone would feel that cancer is far away from them, and they may not be able to encounter it in their lifetime.
Only when you or a friend around you gets cancer do you realize that cancer is so close and you are powerless to do anything about it.
He squeezed it!
The angry young roommate slammed the table: If one day, I mean, if one day I become successful, I will make sure every patient can take medicine!
The hard-working words of the angry young roommate slightly dispersed the solemn atmosphere in the dormitory, and everyone's mood became a little lighter.
They are students majoring in pharmacy. They chose to apply for this major for this purpose. What they cannot do now does not mean that they will not be able to do it in the future.
But at this moment, Lu Liang was the only one who was not feeling relaxed at all.
Because Lu Liang had the same idea as his angry young roommate when he traveled through time.
After traveling through time, Lu Liang immediately discovered one thing, that is, medicines in this world are scarcer than those in the previous world.
For example, for chronic myelogenous leukemia, second-generation drugs that are better than Gleevec have appeared in that world, but in this world, the treatment drug for chronic myelogenous leukemia still remains on Gleevec.
Just as Lu Liang was about to show off his skills, he soon discovered a problem to his frustration.
The second-generation drug dasatinib is a new type of small molecule targeted drug that surpasses Gleevec.
Although Lu Liang had done relevant experiments in his previous life, his research focus at that time was more focused on cutting-edge scientific molecular mechanisms of drugs, and he paid little attention to applied research such as chemical formulas of drugs and drug synthesis routes.
Because there is a big problem in applied research, that is, the paper cannot be published.
If you still want to graduate without a thesis, study for two more years!
After all, fourth-year master's degrees and sixth-year Ph.D.s are not uncommon, there are many of them in universities.
This also resulted in Lu Liang now having no theoretical knowledge, but completely ignorant of the chemical formulas and drug synthesis routes of second-generation drugs.
This feeling is like...knowing the explosion principle of a nuclear bomb. Isn't it the release of energy caused by the bombardment of uranium-235 atoms by thermal neutrons to form a chain reaction?
But the question is, how can we get some uranium-235 to play with?
Thinking of this, Lu Liang sighed unwillingly.
He originally thought that after time travel, he could rely on the pharmaceutical knowledge accumulated in his previous life to change the monopoly of Western pharmaceutical giants in the field of innovative drugs.
Now it seems like, well, it’s better to wash up and go to bed early.
Hurry up and do your homework. You have to hand it in in class tomorrow. I don't know who reminded me.
The angry young roommate who had been so impassioned just now was brought back to reality.
The other two roommates also picked up paper and pens and started their unfinished homework.
In the previous professional class, the teacher assigned an after-school homework.
Check the information alone and draw the synthesis route of small molecule targeted drugs.
This assignment will involve the final exam scores of the professional courses, so it is particularly important to Lu Liang and the others.
So no one will treat it casually.
Brother Lu, have you finished painting? What are you painting? Liu Qi stuck his head out and glanced at Lu Liang.
Gleevec.
Lu Liang replied that he had completed his homework before, and what he chose to draw was Gleevec's drug synthesis route.
As Lu Liang spoke, he moved his gaze to the drawings already drawn on the table.
However, when Lu Liang once again looked at the Gleevec drug synthesis route he had drawn on the paper, he suddenly froze.
Because he saw a strange thing next to the drug synthesis route.
[Level: Lv1 (currently only drugs can be analyzed)]
[Analysis object: Imatinib (Gleevec)]
[A small molecule targeted drug is currently the only drug for the treatment of chronic myelogenous leukemia, which can increase the patient's ten-year survival rate from 50% to 90%. 】
[Source points required for analysis: 1]
[Existing source points: 1]
[Analysis can randomly obtain the synthesis route of the second-generation drug dasatinib (current level lv1, only 1 drug synthesis route can be obtained). 】
【Do you want to analyze? 】
[Friendly reminder: Source points and experience are obtained based on learning and drug sales. The higher the level, the more drug synthesis routes can be obtained through analysis. Medical equipment can be analyzed after level 10. 】
? ? ?
This is……?
Lu Liang was stunned at first, but he seemed to realize something quickly, and his eyes suddenly lit up.
Damn you, you are finally here. How can I live without you?
As a time traveler, Lu Liang certainly knew about the system, and Lu Liang quickly began to study his own system.
Soon, Lu Liang understood the function of the system. The system could analyze the new generation of drugs with better effects based on the existing drugs.
After figuring out how to use the system, Lu Liang chose analysis almost without hesitation.
There was a bang. At the moment when he chose to analyze, Lu Liang felt as if his head had been hit by a big hammer, and his whole head was buzzing.
At the same time, a large number of chemical structural formulas of compounds poured into Lu Liang's mind.
N-hydroxyethylpiperazine, 4,6-dichloro-2-methylpyrimidine...the chemical structural formulas formed a storm in Lu Liang's mind.
Gradually, the storm began to subside, and these chemical structural formulas were arranged one after another, forming a clear synthesis route in front of Lu Liang's eyes.
Lu Liang's eyes widened when he saw this drug synthesis route.
Because that is the synthesis route of dasatinib, a second-generation drug that surpasses Gleevec!
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The author kowtows! !