Rebirth of the God-level Xueba

Chapter 60 Research coenzyme

The reason why Yang Rui’s laboratory used the Xibao Meat Factory to call and purchase equipment is because there is a biochemical pharmaceutical team under the Xibao Meat Factory.

Some people may wonder how can there be a pharmaceutical workshop in the meat factory, but in fact, until the 1990s, most of the biochemical pharmaceutical factories in China were located in the meat factory.

This is determined by the nature of the biochemical pharmaceutical factory. Primary biochemical pharmaceuticals are produced using animal organs. If you want fresh animal organs, you do not have good preservation and transportation methods. Do not set up the factory in a meat joint factory. , Where can it be set?

At this time, the biochemical pharmaceutical factory was not called a biochemical pharmaceutical factory. It was generally called an organ biochemical factory or an organ biochemical workshop. The scale was not large. The Xibao Meat Union Factory had only a team of more than ten people. As far as the unit is concerned, it is already a top-ranking manufacturer in China.

Journals and books related to biopharmaceuticals are either called “Organ Biochemical Pharmacy” or “Animal Biochemical Pharmacy” at this time. The microbial fermentation method and plant cell culture method commonly used in later generations are still under research. Not to mention the chemical synthesis method, this will always be the most difficult and the last method to popularize.

There are many organs that can be used for pharmacy. The pancreas can extract insulin and pancreatin, the heart can extract coenzymes, and the brain can extract cholesterol… For 82 years, all biological products are expensive and have a good market. of.

However, the biochemical pharmaceutical team of the Xibao Meat Union Factory is not taken seriously. Their most profitable project is the export of white strips of meat to Europe, earning millions of dollars in foreign exchange each year, which is also the proud capital of the factory leaders.

In contrast, although the products of organ pharmaceuticals are valuable, the cost is also very staggering. With the method of the 1980s, one kilogram of organs may only be able to extract tens of milligrams of products. During this period, other solvents and materials are consumed, and the gain is not worth the loss. . Moreover, in the 21st century, the biochemical products that are relatively common in the 21st century cannot be produced by the biochemical pharmaceutical team of the Xibao Meat Union Factory. With their technology, what others can do is not cheap, and he can’t do what others can’t.

Of course, Yang Rui does not have such a problem.

After 30 years of development, he used the laboratory practices of later generations, and the output was higher than the biochemical team of the Xibao Meat Union Factory. Of course, the size of the biochemical team at the Xibao Meat Union Factory is actually the size of the laboratory, but it has a few more people.

Yang Rui is not prepared to directly sell biochemical products to make money. These things are still the state’s monopoly model. It is troublesome and tiring for individuals to make big money. Continuous production is prone to errors by trained workers, not to mention him. With a group of students.

It is estimated that it is feasible to get the honor, but Yang Rui does not care the least.

Rather than earning less for honor, Yang Rui is more willing to prepare some papers.

When he was a graduate student, he spent most of his time searching for papers for his teachers. Under normal circumstances, a tutor makes a list and he has to check the information for a week. It is impossible to say that the periodicals and books he has read are integrated, but it is always necessary to scan the past.

As a result, these papers are now in his mind.

Yang Rui just chooses some simple ones to redo the experiment, and then rewrite it.

As for how simple it is to make his own small laboratory run, Yang Rui’s method of judgment is the price of the experimental equipment.

The simpler the equipment, the better, the less equipment used, the better, the simpler the experiment, the better, and the easier to buy raw materials, the better.

After screening in this way, Yang Rui selected the relevant research of coenzyme q10.

Enzymes are catalysts for the work of organisms, and coenzymes are the so-called “second substrates” that assist enzymes in their work. Common coenzymes include vitamin b1, vitamin b2, folic acid and so on. These cheap coenzymes in later generations are all produced by chemical synthesis, and the cost of a bottle can be reduced to a few cents, but at the beginning, they are still obtained by extraction. For example, folic acid, which all pregnant women eat, was first isolated from spinach leaves, and was named after it.

From this point of view, the so-called diet therapy in China is somewhat meaningful.

Coenzyme q10 is a coenzyme that was discovered later and was originally extracted from animal heart tissue. Its research process is very long.

As early as 1974, Japan’s Eisai Pharmaceutical Factory sold it as a heart disease medicine, which attracted the attention of many biologists. As a result, in the next few years, three international symposiums were held in one breath to conduct extensive research on its biomedical and clinical applications. China also made coenzyme q10 in 1976.

And until Yang Rui crossed the road, coenzyme q10 was still a research hotspot. Biologists still studied its biomedical and clinical applications, and pharmaceutical companies still studied its production methods. Although each kind of research has improved a lot, coenzyme q10 is still Not a cheap biochemical product.

In 1982, coenzyme q10 was naturally more valuable, whether it was a product or a research paper.

It is precisely because 30 years later, coenzyme q10 is still a research hotspot, and Yang Rui has been able to read many related papers. As long as the experimental equipment is in place, he can copy a basket of articles.

In fact, experts and professors at home and abroad who have relied on the research of coenzyme q10 for a lifetime are all over the floor. Cutting off the ears can almost fit a basket. There is not much more than Yang Rui, and a lot less than him.

Adhering to the idea of ​​low-key accumulation, Yang Rui first purchased instruments such as beakers, flasks and Erlenmeyer flasks, and reagents such as ethanol and propanol butanol in the name of the school. Directly ordered two batches of coenzyme q10 refined products.

He is going to write an article on how to measure coenzyme q10 more accurately. Compared with the direct production of coenzyme q10, this kind of article is not weak, but it will be simpler.

While waiting for the goods to arrive, Yang Rui began to tutor the members of the Ruixue group in biology, and at the same time selected his own experimental assistants.

Li Tieqiang and others will continue to come to the classroom to listen to the class, but they can no longer get the test papers for free, and Yang Rui will not correct the test papers for them, let alone make a targeted course tilt.

For students who have not enjoyed this kind of treatment, it may be difficult for them to understand the effect of the so-called tilt, but for Li Tieqiang and others who have enjoyed special treatment, they immediately felt the change.

It is difficult to improve performance.

They couldn’t tell the reason, but they were even more panicked.

Someone took advantage of the night to find Yang Rui, hoping to rejoin the Rui Xue group, but was blocked by the roommate Cao Baoming without hesitation.

Li Tieqiang and Wang Wanbin also tried to talk to each other in the cafeteria, but they were still rejected without hesitation.

At the same time, the curriculum of the sharp learning group has gradually progressed from reviewing junior high school, re-learning high school, and progressing to real high school review.

More difficult topics and more complicated review routes further widen the distance between the sharp learning group and other students.

At this time, Li Tieqiang and others regretted it even more, but they were also in vain.

Yang Rui had so many cards in his hand that he completely shielded them without saying what to do.

And the more plain the handling is, the more irritating it is.

Li Tieqiang and Wang Wanbin simply pulled more than a dozen people, organized a study group of their own, and then studied hard and encouraged each other in an attempt to surpass the sharp learning group.

However, they are all veterans who have tried to repeat the studies for two or three years. If the old method is useful, how can they repeat the studies year after year.

What’s more, the members of the Ruixue Group study diligently in a more scientific curriculum schedule. The gap between the two sides will only widen, but it will not shrink.

A week later, when the first batch of simple instruments ordered by Yang Rui arrived, there were only two or three people left in the newly established study group, which was in name only.

More people have set their sights on this laboratory.

In the history of West Castle Middle School, there has never been a laboratory configuration.

Even Principal Zhao couldn’t help coming to this small house by the garden, observing and stroking the simple flasks, burettes, pH test papers and other objects one by one, and sighed, “It’s good if you have been to school two years earlier, Old Tan. Maybe you can stay.”

Lao Tan is a chemistry teacher at a university. Because of ****, he ran to Xi County and was later protected by President Zhao. However, when Yang Rui was in high school, Tan Ping returned to the city.

Yang Rui disapproved of President Zhao’s feelings, and smiled: “The current configuration of this laboratory is not as good as the middle school in the provincial capital, and it is not as complete as a laboratory in Hedong University. Teacher Tan will not be able to do the experiment if he stays. , Can only waste a lifetime.”

“Why is teaching a waste?” Principal Zhao knew that he was right, but he still didn’t want to admit it, and shook his head: “I think your laboratory is good enough. What you want, bottles and cans are better than one in one. There are so many things, what experiments can’t be done?”

Yang Rui smiled, and said: “The laboratory in No. 1 Middle School is for teaching. How can I compare with them. Moreover, in terms of assets, this laboratory is currently only worth 1,000 yuan. How can the No. 1 laboratory cost tens of thousands? .”

“Fart. They received a batch of experimental equipment in 1978. Otherwise, they are still poor and vain.” President Zhao turned his face and rubbed his hands and said, “Or, let the students from our school come to you. Do experiments in this laboratory?”

Yang Rui spread out his hand and said, “It will consume materials to do the experiment. If you are willing to spend money to buy reagents or something, I can substitute for free.”

Principal Zhao was taken aback and asked: “How much money is the material?”

“A few cents per person at a time, depending on the experiment, the average two cents is required.” Prices were cheap in the 1980s, and experimental consumables were not cheap.

Principal Zhao quickly mentally calculated that with more than 400 people in the school, he would get at least RMB 100 for an experiment once a month. For a semester for four months, it would cost RMB 400 or 500.

With this result, Principal Zhao immediately changed his words: “It’s too much trouble to do the experiment. Just such a big room… Let the students visit it for free.”

Yang Rui wanted to say, can the free visit make the room bigger?

However, looking at the curious look of the students around, Yang Rui couldn’t help but say: “Visit for the visit. However, if the visit is free, I will not deliberately arrange the content of the experiment. It is up to me to explain or not to explain, and the visit discipline is also You have to listen to me.”

“no problem.”

“Don’t visit by class anymore. Let interested students sign up, and I will inform them of the time. It is estimated that this will reduce the pressure of the visit.”

“no problem.”

“Students who come to visit should help me clean the laboratory and help clean the experimental equipment.”

“no problem.”

“Let’s do it like this If there are really interested students, I will find opportunities to arrange them to do the experiment in person.” Yang Rui did not wait for Principal Zhao to speak, and then immediately said: “The number of students cannot be large, the school does not have I don’t have any funding.”

I really want to learn something by doing experiments. It’s at least one operation every half a month. It costs 1,000 yuan for a semester and 2,000 upwards for a year. Yang Rui cannot afford it either.

Principal Zhao nodded without hesitation, and then made his request: “Someone will visit in the future, you have to say that the laboratory belongs to the school.”

“Whatever, the instrument is in my name anyway.” Yang Rui still has the invoice in his hand.

Principal Zhao ignored Yang Rui’s Xiao Jiujiu and touched his beard and said: “Shengli Middle School paved a cinder road last year. Dong Gouzi invited me to visit twice. I have to call this place back.”

“If someone comes to visit, you have to notify in advance, otherwise don’t blame me behind closed doors and padlock.” Yang Rui threatened a little. He actually didn’t care if anyone came to see it. Writing a paper is a fame, and a demonstration laboratory is also a fame. You are reading, if any!

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